This volume explores the latest methods used to study various aspects of TET proteins and their biology. Chapters in this book are divided into five parts. Part One describes technologies aimed at detecting and quantifying DNA methylation turnover using massively parallel sequencing, ELISA, and mass spectrometry approaches. Part Two looks

Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread hypomethylation. Here we show that TET loss-of-function results in a similar genomic footprint. Both 5hmC in wildtype genomes, and DNA hypermethylation in TET-deficient genomes, are largely confined to the active euchromatic compartment, consistent with the known functions

Books about Epigenetic Regulation in the Nervous System

Books about Chromatin Regulation in Cell Fate Decisions

Sperm and oocytes are terminally differentiated, sex-specific germ cells, which, upon fertilization will generate a new embryo and leads to species propagation by sexual reproduction. Though fated only to generate eggs or sperm, germ cells have the unique property to imbue zygotes with totipotent capacity, which facilitates the formation of